Sexually Transmitted Infections (STI) has been part of the medical specialty of dermato-venereology. Expertise in this field continues to reside among specialists at the National Skin Centre.
The Department of STI Control (DSC) is part of the NSC, and runs the National STI Control Programme for the Ministry of Health. The department is located at Block 31 Kelantan Lane, Singapore 200031.
The DSC is the only public specialist STI facility in Singapore. It provides comprehensive medical, nursing, laboratory, education and counselling services at subsidised rates. It conducts research in laboratory diagnostics, clinical trials, as well as behavioural and social sciences related to STI/HIV. It also provides training for undergraduates, postgraduates and allied health personnel.
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Clinical Indicator:
Cure rates and antibiotic sensitivity of Gonorrhoea
Background
- In the 1990s, a single dose of Oral Ciprofloxacin 500mg was the standard treatment for Gonorrhoea
- In 1999, the antibiotic resistance of N. Gonorrhoeae to ciprofloxacin had increased to 17% of isolates (>1.0ug/ml).
- Clinical failure rate among DSC patients then was over 6%.
Gonorrhoea – Susceptibility to Ceftriaxone
Action
In view of this, the DSC recommended the cessation of Oral Ciprofloxacin as a treatment for Gonorrhoea with effect from May 2000.
Since 2013, the standard treatment has been a single dose of intra-muscular Ceftriaxone 500mg with oral Azithromycin 1g.
Treatment Outcome Ceftriaxone Injection for Gonococcal Urethritis
Note: Sample size is based on patients who returned for test of cure.
Treatment Outcome for Ceftriaxone Injection For Gonococcal Cervicitis
Note: Sample size is based on patients who returned for test of cure.
Conclusion
- DSC continues to achieve >95% cure rates for patients receiving Ceftriaxone injections for Gonorrhoea Urethritis and Cervicitis.
- If failure rates reaches 5% or more, it may be an indication of possible resistance of Neisseria Gonorrhoea and therefore a need to review antibiotic treatment guidelines.
- DSC continues to closely monitor cure rates and antibiotic sensitivity of Gonorrhoea.
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