OSD usually occurs on the parts of the body which come into contact with work substances. OSDs occur most frequently on the hands and forearms.
Early signs of OSD include dryness, redness and itch of the skin. If severe, the skin may become swollen and vesicles may develop. The skin may eventually become cracked, scaly and thickened.
These skin changes often improve when the worker is away from work, such as during weekends and holidays. Fellow workers who do the same job may also have similar skin problems.